Mechanism of action

Food allergy

In food allergy, Th2 cells drive B cell IgE production, causing an inflammatory cascade.

Dendritic cells detect allergens and start a cellular cascade:

They use key Th2 allergy-inducing cells to drive IgE production by B cells

IgE coats and sensitizes effector cells

Allergenic protein binds to IgE on mast cells

Mast cells trigger degranulation and inflammatory cascade, causing typical symptoms

Oral immunotherapy

Oral immunotherapy both desensitizes mast cells and reduces IgE production

It promotes protective Treg cells and IgG4 antibodies

The desensitized mast cells and basophils lack IgE and become unresponsive

Problem of large, fortnightly dose increases

Large dose increases result in more frequent and severe side effects.

Episodes of adrenaline use are 5x higher with large dose increments
Source: FDA presentation at Palforzia® Advisory Committee following phase 3 trial ‘Palisade’

The US Food and Drug Administration (FDA) requires these large increments to be conducted in certified clinics under specialist supervision and monitored for at least an hour.

This places significant burden on patients and physicians.

Camallergy’s approach: at-home up-dosing

Tiny, daily dose increments replace large, fortnightly dose increases.

Removing large dose increases aims to reduce side effects.

We aim to enable all up-dosing to take place safely at home.

Disclaimer

The safety and efficacy of the Camallergy’s treatments are subject to confirmation in phase 3 clinical trials. They are investigational and not yet approved by regulatory authorities.